Describe how RNA polymerase backtracking could function to increase the fidelity

Question

Describe how RNA polymerase backtracking could function to increase the fidelity of transcription. Drag the terms on the left to the appropriate blanks on the right to complete the sentences.

If ______translocation slows down, the ______ process will occur more often. Just as we have seen with the 3' to 5'_____ activity of DNA polymerases, the main fidelity gain probably comes from _____ extension of a mismatch (______ KM for extension from a mismatch). The backtracking activity allows the polymerase to make a second attempt instead of just falling off. Because the probability of repeating an error is_______ , the second attempt to transcribe that same stretch of DNA has a _______ probability of transcribing it accurately.

Word Bank:

reverse

slow

decreased

high

low

endonuclease

forward

fast

increased

exonuclease

Explanation / Answer

if REVERSE translocation slow down,the ENDONUCLEASED process will occur more often.just as we have seen with the 3' to 5' EXONUCLEASE activity of dna polymerases,the main fidelity gain probably comes from FORWARD extensition of mismatch (DECREASED KM for extension from a mismatch).the backtracking activity alloys the polymerase to make the second attempt insted of just falling off.because the poroballity of repeating an error is HIGH,the second attempt to transcibe that same srech of dna has a LOW probality of transcribing it accurately

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