This pedigree shows the inheritance of a rare autosomal recessive disorder. This

Question

This pedigree shows the inheritance of a rare autosomal recessive disorder.

This pedigree shows the inheritance of a rare autosomal recessive disorder. a. Write genotypes for each individual in the pedigree (Use A and a to represent the alleles). If a genotype cannot be estimated with certainty, use a dash to indicate the unknown allele (e.g. A-). b. II-2 and II-3 are planning to have a child. What is the probability that this child will have Tay-Sachs disease? Explain how you calculated your answer.

Explanation / Answer

a. I-1: aa or Aa

I-2: Aa or aa

I-3: aa or Aa

I-4: Aa or aa

b. As per the given pedigree, both II-2 and II-3 are the carriers of the diseases, so they have 50% probability of having the child with Tay-Sachs disease.

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