The reaction should for a of minutes. Develop the TLC plate in the developing ch
ID: 485844 • Letter: T
Question
The reaction should for a of minutes. Develop the TLC plate in the developing chamber previously stir total 40 reaction is prepare and visualize the spots with a Uv amp. Do the TLC results indicate that the complete at any of those given times? Be sure to sketch your TLC plates in the observations. Reaction work-up Once the reaction is complete, add 10 mL of cold water to the Erlenmeyer flask. Place the Erlenmeyer flask in an ice bath to allow the product to precipitate. If the product does not precipitate within 10 minutes, a 1-2 mL of cold water and scratch the surface of the with a flask glass stir rod to induce crystallization. Collect the solid using vacuum filtration. Wash the solid with several 1-2 mL portions of cold water and allow the product to air dry for at least 10 minutes.
Explanation / Answer
A) The reduction of benzophenone with NaBH4 to form diphenyl methanol is carried out.
the reaction is performed in methanol as the solvent for the reaction
after the reaction is done, added is cold water, which protonates the O- species to form alcohol.
the alcohol thus formed is insoluble in the solution and precipitates out.
filter the solid and wash with ice-cold water several times
dry the solid in air
weigh the product and calculate the yield of the reaction
B) the reactants and the products are separated by using silica gel column chromatography. the eluting solvent used is pet-ether and ethyl acetate. Benzophenone being the less polar compound, comes out of column first and then diphenyl methanol is eluted out at the end.
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