I have a exam comming up and i am struglging can you please answer these questio

Question

I have a exam comming up and i am struglging can you please answer these question in as much details as possible please do not leave small answers, if you going to just write a few sentences and ignore questions pelase do not waste my question as i will just give it a negative review.

35. Determine the solubility of phenobarbital in a mixture of 20 mL water and 45 mL ethanol, given Solubility in water -1g in 1000 mL Solubility in ethanol 1 g in 8 mL (5 marks) 36. Citing examples, briefly discuss the advantages in using non-aqueous solvents to formulate topical drug products (5 marks)

Explanation / Answer

35. Solubility of phenobarbitol is 1 g in 1000ml

We have a solution in which only 20 ml of water is present so solubility of phenobarbitol in 20 ml = 20 /1000 = 0.02

Then solubility in ethanol is 1g in 8ml

We jave 45 ml of ethanol so solubility will be given as 45 / 8 = 5.625

So the total solubility of phenobarbitol in solution will be (0.02 + 5.625) = 5.645

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