a) Identify the number of activating and deactivating groups on each ring b) Bas
ID: 495167 • Letter: A
Question
a) Identify the number of activating and deactivating groups on each ring
b) Based on your answer to the previous question, which ring of Diclofenac would be more activated toward electrophilic aromatic substitution?
Left, right, or equally activated
Diclofenac, a non steroidal antiinflammatory drug, possess two aromatic rings. Identify the number of activating and deactivating groups on each ring by typing the correct number in the boxes provided. For example, if you believe the left ring possesses 5 activating groups, you would type "5" (no quotes) in the box COSH CI Diclofenac Right Activating: Left Activating: Right Deactivating: Left Deactivating:Explanation / Answer
Left activating: 1
Left deactivating: 2
Right activating: 1
right deactivating: 1
-NH groups is activating group and -Cl is a weak deactivating. -COOH is a strong ring deactivatng group.
b) Left ring is more activated towards electorphilic aromatic substitution reaction because -COOH is a strong deactivationg group.
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