You want to study the cell cycle in fish embryo cells, in which the cell cycle l

Question

You want to study the cell cycle in fish embryo cells, in which the cell cycle length is about 30 min. You examine the amount of M-cyclin in these cells and see that it varies over the cell cycle. Your friend works in a pharmaceutical company where they are making drugs that block the cell cycle. She gives you some of their secret drug, called MI575, and you add it to cells, examine M-cyclin, and get the results shown in Figure 1.

Figure 1

A.        From these data, would you predict that cells treated with MI575 are arrested in the cell cycle at various stages (G1, S, G2, or M), or do you predict that cells will be blocked at a particular stage? If you think cells will be blocked at a particular stage, describe the stage at which you think the cells would be blocked.

B.        From the data, propose a simple molecular explanation for how MI575 acts to block the cell cycle.

Explanation / Answer

A. mitotic inhibhitors blocks the cell cycle by inhibiting the tubulin which can furthur prevent microtubule polymerization . these inhibhit by the inhibhiting of cyclin dependent kinases .the cell cycle is blocked at G2 phase , where it prevent the damaged DNA entering into the mitotic phase

B. mechanism of action of MI 575 ; it mainly act by activation the wee 1 kinases this causes the inhibhiton of the CDK 1 activity whch prevent it by binding to cyclin B and prevent entry into M phase at G2/ M check point

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