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When a disulfide linkage is formed, the compound containing this new linkage has

ID: 511871 • Letter: W

Question

When a disulfide linkage is formed, the compound containing this new linkage has been hydrolyzed. dehydrated. electrolyzed. oxidized. reduced In conventional peptide synthesis, the nitrogen of a given amino acid must be deactivated or blocked while the carboxyl group is activated. Which of the following reagents is used to protect the amino group of an amino acid? di-tert-butyl dicarbonate dicyclohexylcarbodiimide ninhydrin trifluoroacetic acid phenylisothiocyanate In peptide synthesis, give the use of dicyclohexylcarbodiimide. activates the carboxyl group of an amino acid protects the carboxyl group of an amino acid protects the amino group of an amino acid activates the amino group of an amino acid removes the protecting group on the N-terminal amino acid

Explanation / Answer

Ans 4. D) oxidised

In biological context , the disulfide linkages are formed in between sulfhydryl groups ( -SH). These groups are oxidised by air and hydrogen peroxide. Iodine can also be used to oxidise thiols to disulfides in laboratory.

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