A key difference between small interfering RNAs (siRNAs) and micro RNAs (miRNAs)

Question

A key difference between small interfering RNAs (siRNAs) and micro RNAs (miRNAs) is that__________.

siRNAs are created from double stranded RNA templates by the enzyme DICER, miRNAs are directly encoded.

Only miRNAs interact with proteins to create the RNA-induced silencing complex (RISC)

siRNAs tend to base pair perfectly with their target, whereas miRNAs have imperfect base pairing.

siRNA –RISC complexes interact with the 5’ end of their target transcript, whereas miRNA-RISC complexes interact with the 3’ end of their target.

miRNA –RISC complexes interact with the 5’ end of their target transcript, whereas siRNA-RISC complexes interact with the 3’ end of their target.

siRNAs are created from double stranded RNA templates by the enzyme DICER, miRNAs are directly encoded.

Only miRNAs interact with proteins to create the RNA-induced silencing complex (RISC)

siRNAs tend to base pair perfectly with their target, whereas miRNAs have imperfect base pairing.

siRNA –RISC complexes interact with the 5’ end of their target transcript, whereas miRNA-RISC complexes interact with the 3’ end of their target.

miRNA –RISC complexes interact with the 5’ end of their target transcript, whereas siRNA-RISC complexes interact with the 3’ end of their target.

Explanation / Answer

ANS: C IS TRUE

si RNA binds perfectly to its mRNA target and it is perfect match to the sequence. si RNA ha 100%perfect match and therefore siRNA knock down specific genes ,with rate exceptions.where as miRNA in contrast it can inhibit translation of many different mRNA sequences because its pairing is imperfect.

A, B are untrue because both play role in epigenitics through a process called RNA-RITS, and both are processed inside the cell by the enzyme called DICER.

Related Questions

Navigate

• Browse (All)
• Browse A
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.