Levels of a signaling molecule, F-2,6-BP, regulate glycolysis and gluconeogenesi

Question

Levels of a signaling molecule, F-2,6-BP, regulate glycolysis and gluconeogenesis. The target enzymes are phosphofructokinase 1 in glycolysis and fructose-1,6-bisphosphatase in gluconeogenesis. Use this information to answer the question.

Part A

The graph shows the activity of fructose-1,6-bisphosphatase in the presence and absence of F-2,6-BP. Which statement below is NOT supported by the information provided in the graph?

Decreasing levels of F-2,6-BP decrease the Km of fructose-1,6-bisphosphatase. In the presence of F-2,6-BP, fructose-1,6-bisphosphatase activity is completely inhibited. Fructose-1,6-bisphosphatase activity is the highest when F-2,6-BP levels are low. The absence of F-2,6-BP increases the affinity of fructose-1,6-bisphosphatase for its substrate. no F-2,6-BP with F-2,6-BP

Explanation / Answer

From the given graph of fructose-1,6-BP versus activity

the one which is not sufficiently supported by the data given in the graph is,

Decreasing levels of F-2,6-BP decreases the Km of fructose 1,6-bisphosphate

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