Which of the following coenzymes is NOT tightly/covalently bound to the pyruvate

Question

Which of the following coenzymes is NOT tightly/covalently bound to the pyruvate dehydrogenase complex (PDC)? A. FAD B. Lipoic acid C. NAD^+ D. TPP Which of the following statements is FALSE concerning the pyruvate dehydrogenase complex? A. FADH_2 is a product. B. It uses coenzyme A as a substrate. C. It requires TPP as a coenzyme. D. Lipoic acid is covalently bound to E2. E. Pyruvate is oxidized to acetyl-CoA, therefore linking glycolysis and the citric acid cycle. Which enzyme-catalyzed reaction in the citric acid cycle generates H_2O? A. The reaction catalyzed by citrate synthase B. The reaction catalyzed by fumarase C. The reaction catalyzed by aconitase D. None of the listed choices is correct.

Explanation / Answer

2. TPP (Thymine pyrophosphate) is losely bound to complex. While, lipomide and FAD are covalently bonded. While NAD+ is cosubstrate.

3. Statement A is FALSE. FADH2 is again oxidized by NAD+ to get NADH2 . So NADH2 is the product.

4. C is the answer . The reaction catalyzed by aconitase

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