Protein synthesis is a relatively accurate process in both prokaryotes and eukar
ID: 52683 • Letter: P
Question
Protein synthesis is a relatively accurate process in both prokaryotes and eukaryotes. During chain elongation, if the average error frequency is one incorrect amino acid inserted per every 2000 translated.
What percentage of full length dystrophin polypeptides (3500 aa long) will have exactly the amino acid sequence specified in the mRNA? Assume that the observed error frequency during translation is based on independent probabilities for inserting an incorrect amino acid (i.e. the occurrence of an error has no impact on the probability of another error occurring).
Explanation / Answer
Total dystrophin polypeptide length = 3500 amino acids
incorrect amino acid incorporation at every 2000 codons, therefore dystrophin protein molecule will contain at least one misincorporated amino acid
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