Different proteins have different functions and must be localized to the appropr

Question

Different proteins have different functions and must be localized to the appropriate location in the cell. Look up the function of the protein "PML" in NCBI Gene http://www.ncbi.nlm.nih.gov/gene/ or Uniprot http://www.uniprot.org/uniprot/. Based on the function of this gene select the following logical assumptions that can be made. Select all statements that could be correct.

A. The sequence for PML contains a C terminal KDEL

B. After translation PML interacts with SRP

C. The sequence for PML contains a short stretch of Lysine and Arginines

D. After translation PML interacts with a mitochondrial import receptor

E. PML has a hydrophobic transmembrane domain

F. The sequence for PML contains a NLS

G. After translation PML interacts with a nuclear import receptor

H. PML is glycosylated

Explanation / Answer

The sequence for PML contains a short stretch of Lysine and Arginines.

PML has a hydrophobic transmembrane domain

The sequence for PML contains a NLS.

After translation PML interacts with a nuclear import receptor.

The statements C, E, F and G are correct.

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