Hello everyone, I am preparing for an exam soon and there is a picture in my boo

Question

Hello everyone,

I am preparing for an exam soon and there is a picture in my bookthat shows a depiction of cell signaling pathways, leadingfrom binding of the cholera toxin to the constitutive activation ofintestinal CFTR (cystic fibrosis) channels. I am VERY confused withwhat the picture is trying to show (in a general way). Can someonebreak it down to tell me the crux of what this concept is?

I looked online and while I can't find the exact same picture ofwhat is in my book, I found the closest one:

http://www.jyi.org/articleimages/610/originals/img1.jpg

http://www.bmsc.washington.edu/WimHol/figures/figs2/Pickens-Moon.JPG

http://www.jleukbio.org/content/vol75/issue5/images/medium/jleub755cvf1.gif


^^^ In other words, what are these pictures trying to show me aboutthe cholera toxin?

I will rate lifesaver for sure for someone who can put it in asimpler way (in their own words).

Thanks!

Explanation / Answer

Third part first: Toxin, secreted by bacterium Vibrio cholera, issecreted and binds to a host cell receptor (you). Endocytosisoccurs where the receptor (your cell) forms a complex (a sort ofpartnership) with the invader. The complex then dissociates(no more partnership) and the poison that was hanging onto the cellis released. Inside the cell. Making for some rathernasty moments. Second part show the invader as joining the cell. Note thatthe cell toxin does not have to invade the tissues proper to wreckhavoc. First part: Very much like the third: It activates adenylatecyclase, raises cAMP of cells, so the elecric gradient of theepithelial cells cuases the release and loss of water and vitalsalts.

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