Starting with the segment of a double-stranded DNA molecule show, give the seque

Question

Starting with the segment of a double-stranded DNA molecule show, give the sequence of the molecule resulting from each of the mutations indicated below. Show 3' and 5' ends, and write mutant base pairs in lowercase letters. (Position numbers below refer the top strand.) A transition at base pair position 5 A transversion at base pair position 5 A deletion of two base pairs at positions 4 and 5, respectively An insertion of three base pairs between base pairs 5 and 6 An inversion of the three base pairs beginning at position 3 The mutant allele of a tumor suppressors gene is inherited through the maternal line recessive to the normal allele dominat to the normal allele inherited through the paternal line The normal genes that are found in the genome of an organism and that have the potential to transform a cell to a cancerous cell if they are activated are called proto-oncogenes anti-oncogenes retro-genes fragile site genes Which of the following would not be a function of an oncogene? code for a tyrosine kinase code for a DNA-binding protein code for a GTP-binding protein code for a gap protein The genetic material in a retrovirus is + strand RNA - strand DNA dsRNA dsDNA

Explanation / Answer

9.

(a) 3’-TTGGtACCTT-5’

(b) 3’-TTGGg/cACCTT-5’

(c) 3’-TTGACCTT-5’

(d) 3’-TTGGAXXXACCTT-5’

(e) 3’-TTGXXXGAACCTT-5’

6. B. recessive to the normal allele

7. A. proto-oncogenes

8. A. code for a tyrosine kinase

10. A. +Strand RNA

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