Differential Tissue Response to a Hormone Epinephrine activates glycogen phospho

Question

Differential Tissue Response to a Hormone

Epinephrine activates glycogen phosphorylase in skeletal muscle cells but not adipose cells. Check all of the possible explanations for this observation.

1.Adipose cells may not express epinephrine receptors.

2.Adipose and skeletal muscle may express different epinephrine receptors.

3.Adipose may express a receptor with higher affinity for epinephrine than the skeletal muscle receptor.

4.Adipose may not have a signal transduction pathway coupled to an epinephrine receptor.

5.Adipose may have a receptor and signal transduction pathway but expresses different proteins when exposed to epinephrine.

Explanation / Answer

Epinephrine activates glycogen phosphorylase in skeletal muscle cells but not adipose cells because Adipose and skeletal muscle may express different epinephrine receptors. Option 2 is correct. In adipose tissue Insulin stimulates the fatty acid synthase to synthesize triglycerides and also inhibits the synthesis of fatty acids by hormone sensitive lipase activated by epinephrine. Thus, epinephine receptors on skeletal muscles and adipose tissues are different receptors.

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