The chemical structure of the acid form of acetylsalicylic acid is shown below w

Question

The chemical structure of the acid form of acetylsalicylic acid is shown below with it:s speciation plot. The dashed line shows the conjugate base form. acetylsalicylic acid (Aspirin) acidic hydrogen 0% 0.9 0.8 0.7 0.6 0.5 LL 0.4 0.3 0.2 _conjugate base -acid 0 123 4 5 67810 11 12 13 14 pH The pH in the stomach is about 1, and in the intestine it is about 5 Select the correct statement below (a) The drug is absorbed from the intestine because it is in a neutral fat-soluble acidic form. (b) The drug is absorbed from the stomach because it is in a neutral fat-soluble acidic (c) The drug is absorbed from the intestine and the stomach because it is in a neutral (d) The drug is absorbed from the intestine because it is in a neutral fat-soluble basic (e) The drug is absorbed from the stomach because it is in a neutral fat-soluble basic form. fat-soluble form in both. form. form.

Explanation / Answer

Option c is correct.

Stomach and intestine both have acidic pH and the given compound aspirin will not ionize at that pH. And will absorbed through membrane (its fat soluble) from stomach and intetine both.

After getting into plasma and basic pH it will generate salicyclic acid as active compund or drug in the body.

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