1. If A1 is an advantageous, dominant allele and A2 is a detrimental, recessive
ID: 55372 • Letter: 1
Question
1. If A1 is an advantageous, dominant allele and A2 is a detrimental, recessive allele, give the change in frequency of A1 (p) in the next generation if: p = 0.2, q = 0.8 and s = 0.25
2. If A1 is an advantageous, partially-dominant allele and A2 is a detrimental, partially-recessive allele, give the change in frequency of A2 (q) in the next generation if: p = 0.5, q = 0.5, s = 0.4 and h = 0.5
3. For a genetic system that displays heterosis (heterozygote advantage), give the changes in frequency of both A1 and A2 (p and q) if: p = 0.3, q = 0.7, s1 = 0.4 and s2 = 0.7 (in this case I deviate from Futuyma’s notation; s1 is the selection coefficient for A1 homozygotes and s2 is the selection coefficient for A2 homozygotes. These are listed as s and t in the text)
4. For a situation where the fitness of a heterozygote is less than that of either homozygote, give the proportion of alleles A1 and A2 in the populations over the next FIVE generations in the future if: p = 0.65, q = 0.35, s1 = 0.02 and s2 = 0.9 (remember, in this case the relative fitness of the homozygotes will be 1 + s. The initial conditions you are given here are considered generation zero)
Provide a graph of the proportions of A1 and A2 in the population against time (measured in generations)
Explanation / Answer
1 - s q2
p= 0.25 (0.2)(0.8)2/1-0.25(0.8)2
=0.038
s p q2 p = __________1 - s q2
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