What is a sensitized sheep RBC and why can\'t we use regularsheep RBC for this e

Question

What is a sensitized sheep RBC and why can't we use regularsheep RBC for this experiment? Briefly explain how a complement fixation test is used todetermine the etiological agent of a disease or in other words whatdoes this test tell us about the patient. What is a sensitized sheep RBC and why can't we use regularsheep RBC for this experiment? Briefly explain how a complement fixation test is used todetermine the etiological agent of a disease or in other words whatdoes this test tell us about the patient.

Explanation / Answer

complementation test : 1.A fourfold increase of titer seen with paired sera analyzed inparallel is considered as indication for an acute infection. Hightiters observed in both samples are considered as indication of arecent or still ongoing (chronic) infection. 2.To differentiate between both possibilities, further analysis ofthe sera by more precise methods (e.g. IgM, IgG-specific tests) isnecessary. 3.A significant decrease in titer seen with paired sera isconsidered evidence of convalescence from a recentinfection

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