Homer, who is affected with a particular disease, is married to Marge, a phenoty
ID: 56705 • Letter: H
Question
Homer, who is affected with a particular disease, is married to Marge, a phenotypically normal woman. They have ten children: 6 normal boys and 4 girls with the disease. Characterize each of the following modes of inheritance as: impossible (I), unlikely (U), probable (P). Justify your answers.
The options are the following: Autosomal dominant, autosomal recessive, y-linked, x-linked dominant, and x-linked recessive.
I don't think that autosomala dominant and recessive are possible. But my friends seems to think it would be unlikely not impossible. Thoughts? I know that if they're crossed there's a 50/50 chance of all children having the disease and not. Which is very close to the actual amount, however the all boys being unaffected and the girls not throws me off.
Explanation / Answer
This will be a case of X linked dominant trait. because in case of autosomal dominant all boys and girls will have same probability of being affected.
In the case of autosomal recessive Two unaffected people who each carry one copy of the mutated gene for an autosomal recessive disorder (carriers) have a 25 percent chance with each pregnancy of having a child affected by the disorder.
In X linked recessive traits a woman who carries an X-linked recessive disorder has a 50 percent chance of having sons who are affected and a 50 percent chance of having daughters who carry one copy of the mutated gene
Y linked traits only affects males.
In X linked dominant traits:A man passes on his Y chromosome to all of his sons and his X chromosome to all of his daughters. Therefore, the sons of a man with an X-linked dominant disorder will not be affected, but all of his daughters will inherit the condition
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