We indicated that Phospholipase C can degrade phosphatidylinositol 4,5 bisphosph

Question

We indicated that Phospholipase C can degrade phosphatidylinositol 4,5 bisphosphate. What is the predicted effect of the phospholipase C (PLC) inhibitor, U-73122, on PKC (protein kinase C)?

PKC activity is increased with the PLC inhibitor because there is more Diacylglycerol and inositol tris phosphate

PKC activity is decreased with the PLC inhibitor because there is more Diacylglycerol and inositol tris phosphate

PKC activity is decreased with the PLC inhibitor because there is less Diacylglycerol and inositol tris phosphate

PKC activity is increased with the PLC inhibitor because there is more Diacylglycerol and inositol tris phosphate

PKC activity is decreased with the PLC inhibitor because there is more Diacylglycerol and inositol tris phosphate

PKC activity is decreased with the PLC inhibitor because there is less Diacylglycerol and inositol tris phosphate

Explanation / Answer

PKC activity is increased with the PLC inhibitor because there is more Diacylglycerol and inositol tris phosphate

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