The [____] that prevent the low-density lipoprotein (LDL) receptor from concentr

Question

The [____] that prevent the low-density lipoprotein (LDL) receptor from concentrating in coated pits lie within the [____] of the receptor, and a single amino acid change, such as tyrosine to cysteine, can disrupt the [____] of the LDL receptor. The internalization signals bind to adaptin proteins, which in turn bind [____] on the cytosolic side of the membrane. In the absence of a function internalization domain, the receptor fails to associate into a coated pit and vesicle for removal of [____] from the serum.

(1) drugs; extracellular binding site; function; COPII; low-density lipoprotein

(2) mutations; cytoplasmic tail; internalization signaling domain; clathrin; cholesterol

(3) temperature-sensitive mutations; trans-membrane domain; internalization; COPI; triglycerides

(4) familial disorders; cytosolic domain; concentration; internalization domain; free fatty acids

(5) amino acid substitutions; substrate-binding domain; activity; clathrin; esterified cholesterol

Explanation / Answer

Based on the given data,

The [amino acid substitutions] that prevent the low-density lipoprotein (LDL) receptor from concentrating in coated pits lie within the [substrate-binding domain] of the receptor, and a single amino acid change, such as tyrosine to cysteine, can disrupt the [activity] of the LDL receptor. The internalization signals bind to adaptin proteins, which in turn bind [clathrin] on the cytosolic side of the membrane. In the absence of a function internalization domain, the receptor fails to associate into a coated pit and vesicle for removal of [esterified cholesterol] from the serum.

Thus, the correct option is (5).

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