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Order the events listed such that they properly and sequentially detail the proc

ID: 58364 • Letter: O

Question

Order the events listed such that they properly and sequentially detail the process of excitation-contraction coupling.

Question 7 options:

High levels of cytosolic calcium in the skeletal muscle cell cause calcium to contact and bind to the regulatory protein, troponin.

Spread of an action potential along the plasma membrane of a skeletal muscle cell and its T-tubule system causes release of calcium from the sarcoplasmic reticulum within the muscle cell.

Removal of the inhibitory effect that tropomyosin had previously been exerting within the sarcomere when it had been lying atop and covering the actin binding sites of the thin filaments, leaves the thick and thin filaments finally able to interact with one another and form crossbridges needed for muscle contraction and shortening.

Troponin undergoes a shape-change that causes it to twist and tug on and re-position the other regulatory protein - tropomyosin - to which the troponin is also attached.

The re-positioning of tropomyosin, in response to troponin's binding of calcium, exposes previously hidden actin binding sites.

Within the skeletal muscle cell, cytosolic levels of calcium increase.

High levels of cytosolic calcium in the skeletal muscle cell cause calcium to contact and bind to the regulatory protein, troponin.

Spread of an action potential along the plasma membrane of a skeletal muscle cell and its T-tubule system causes release of calcium from the sarcoplasmic reticulum within the muscle cell.

Removal of the inhibitory effect that tropomyosin had previously been exerting within the sarcomere when it had been lying atop and covering the actin binding sites of the thin filaments, leaves the thick and thin filaments finally able to interact with one another and form crossbridges needed for muscle contraction and shortening.

Troponin undergoes a shape-change that causes it to twist and tug on and re-position the other regulatory protein - tropomyosin - to which the troponin is also attached.

The re-positioning of tropomyosin, in response to troponin's binding of calcium, exposes previously hidden actin binding sites.

Within the skeletal muscle cell, cytosolic levels of calcium increase.

Explanation / Answer

Based on the given data, the order of excitation-contraction coupling is as follows:

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