11. Peptide bond formation catalyzed by a wild type (WT) ribosome exhibits a tra

Question

11. Peptide bond formation catalyzed by a wild type (WT) ribosome exhibits a transition state enthalpy change H± = +14.0 kcal/mol and TS± = +2.0 kcal/mol. A mutant (MUT) ribosome catalyzes the same reaction with H± = +14.0 kcal/mol and TS± = +0.5 kcal/mol. Assuming everything else between the WT and MUT ribosome reactions is equal, circle or highlight the best answer.

(a) the rate constant for the WT ribosome is < the rate constant for the MUT ribosome

(b) the rate constant for the WT ribosome is > the rate constant for the MUT ribosome

(c) the rate constants for the WT ribosome = the rate constant for the MUT ribosome

Explanation / Answer

Answer: (b) the rate constant for the WT ribosome is > the rate constant for the MUT ribosome

G = H TS

for WT G = 14-2 = +12 kcal/mol

for MUT G = 14-0.5 = +13.5 kcal/mol

lower value of G represents spontaneous process and will have higher rate.

Hence (b) the rate constant for the WT ribosome is > the rate constant for the MUT ribosome is the correct option

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