Research question summary 1. State the hypothesis that is being tested in this r

Question

Research question summary

1. State the hypothesis that is being tested in this research study?

2. What is the experimental design that was used?

3. Which statistical tests are used?

Clinical Research Nutrition in Clinical Practice Volume 26 Number 4 August 2011 463-473 © 2011 American Society for Parenteral and Enteral Nutrition 10.1177/0884533611413778 http://ncp.sagepub.com The Effects of an Oral Supplement Enriched With Fish Oil, Prebiotics and Antioxidants on Nutrition Status in Crohn's Disease Patients ttp://online.sagepub.com Dawn M. Wiese, MD'; Bret A. Lashner, MD, MPH Edith Lerner, PhD*; Stephen J. DeMichele, PhD*; and Douglas L. Seidner, MD 5 Financial disclosure: This study was funded by Abbott Nutrition, Columbus, Ohio. All components of the study, including data analysis and manuscript preparation, were completed at the Cleveland Clinic, Cleveland, Ohio. This research was supported in part by the National Institutes of Health, National Center for Research Resources (CTSA ULIRR024989), Cleveland, Ohio Background: Research in the treatment of Crohn's disease (CD) decrease in plasma phospholipid levels of arachidonic acid with supports anti-inflammatory benefits of n-3 fatty acids from fish increases in eicosapentaenoic acid (EPA) and docosahexaenoic oil, prebiotics and antioxidants. A nutritionally balanced inflam- acid. Ten patients had a final EPA concentration of >2%. There matory bowel disease nutrition formula (IBDNF) enriched with was improvement in fat-free and fat mass in patients with final these compounds has the potential to improve nutrition status EPA >2% (P = .014 and P .05). Vitamin D (25-OH) levels and disease activity in CD. Methods: This is an open-label pilot mproved in all patients (18.5-25.9 ng/mL, P 2% had significantly lower CDAI (116 ± 94.5 vs CD patients. Twenty-eight patients with active CD on stable 261.8 ± 86.5: P = .005) and higher IBDQ (179.1 ± 26.6 vs medication were asked to consume 16 oz of IBDNF/d for 4 I 14.6 ± 35.9, P

Explanation / Answer

State the hypothesis that is being tested in this research study?

Fish oil, prebiotics and antioxidant foods are claimed to improve the immune response and has claimed to improve the nutrition status in the Chorn's disease.

2. What is the experimental design that was used?

28 human models were taken and were given with the prescribed diet for 4 months. The CDAI - Chron's disease activity index and Inflammatory bowel disease questionnaire was given to analyze the result.

3. Which statistical tests are used?

Mean and SD was calculated for open statistics data. For descriptive statistics Fischer's exact test for categorical data and t tests for non parametric data and Wilcox rank sum tests for continuous variables were performed.

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