Research question summary cont. 4. What are the primary outcomes (primary depend
ID: 58753 • Letter: R
Question
Research question summary cont.
4. What are the primary outcomes (primary dependent variables) in the study?
5. What in your opinion were the most important findings?
6. What are the implications of this research?
Clinical Research Nutrition in Clinical Practice Volume 26 Number 4 August 2011 463-473 © 2011 American Society for Parenteral and Enteral Nutrition 10.1177/0884533611413778 http://ncp.sagepub.com The Effects of an Oral Supplement Enriched With Fish Oil, Prebiotics and Antioxidants on Nutrition Status in Crohn's Disease Patients ttp://online.sagepub.com Dawn M. Wiese, MD'; Bret A. Lashner, MD, MPH Edith Lerner, PhD*; Stephen J. DeMichele, PhD*; and Douglas L. Seidner, MD 5 Financial disclosure: This study was funded by Abbott Nutrition, Columbus, Ohio. All components of the study, including data analysis and manuscript preparation, were completed at the Cleveland Clinic, Cleveland, Ohio. This research was supported in part by the National Institutes of Health, National Center for Research Resources (CTSA ULIRR024989), Cleveland, Ohio Background: Research in the treatment of Crohn's disease (CD) decrease in plasma phospholipid levels of arachidonic acid with supports anti-inflammatory benefits of n-3 fatty acids from fish increases in eicosapentaenoic acid (EPA) and docosahexaenoic oil, prebiotics and antioxidants. A nutritionally balanced inflam- acid. Ten patients had a final EPA concentration of >2%. There matory bowel disease nutrition formula (IBDNF) enriched with was improvement in fat-free and fat mass in patients with final these compounds has the potential to improve nutrition status EPA >2% (P = .014 and P .05). Vitamin D (25-OH) levels and disease activity in CD. Methods: This is an open-label pilot mproved in all patients (18.5-25.9 ng/mL, P 2% had significantly lower CDAI (116 ± 94.5 vs CD patients. Twenty-eight patients with active CD on stable 261.8 ± 86.5: P = .005) and higher IBDQ (179.1 ± 26.6 vs medication were asked to consume 16 oz of IBDNF/d for 4 I 14.6 ± 35.9, PExplanation / Answer
The primary outcomes (primary dependent variables) in the study are that a nutritionally balanced inflammatory bowel disease nutrition formula (IBDNF) has the potential (1) to deposit fat-free and fat mass, (2) to improve the status of vitamin D, and (3) to improve the quality of life in Crohn's disease (CD) patients.
The most significant finding is the ability of IBDNF in improving the quality of life in CD patients.
The implication of this research is that Oral supplements enriched with fish oil, antibiotics, and prebiotics have a positive effect on the nutrition status of Crohn's Disease patients and as a result on the quality of their life.
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