Dinitrophenol was once used as a component of diet pills for weight loss however

Question

Dinitrophenol was once used as a component of diet pills for weight loss however, users were dying due to its consumption because the drug cause the inner mitochondrion membrane to become highly permeable which prevented ATP synthesis. How?
a. After coenzymes dropped off electrons, they diffused into the intermembrane space from the matrix
b. Electrons diffused from the matrix to the intermembrane space
c. Protons diffused from the intermembrane space to the matrix, by-passing ATPsynthase
d. Pyruvate is not allowed to enter the matrix

Explanation / Answer

c.Protons diffused from the intermembrane space to the matrix, by-passing ATPsynthase

DNP (dinitrophenol),TRANSPORT PROTONS TO FLOW ACROSS THE INNER MITOCHONDRIAL MEMBRANE WITHOUT atp synthase

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