a. Which project would you pick? b. Why do you think this project is important?

Question

a. Which project would you pick?

b. Why do you think this project is important?

c. What kind of experiments would you do?

e Chegg Study! Guided So ×YDS My Grades-201508-BIOL xy D sciencecases.lib.buffalo.ec × D sciencecases.lib.buffalo.edu/cs/files/.nsulin-signaling.pdf ABP NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE Part IlIl Insulin Resistance "In this lab we are focusing on insulin resistance; the primary cause of type-2 diabetes. This means that even through insulin is present in the blood stream, the cells don't respond as robustly. Type-2 diabetes occurs as a result of continuous insulin signaling due to genetics, poor diet, obesity, and lack of exercise. This continuous over stimulation of insulin signaling alters how the insulin receptor and its down-stream signaling pathways will respond to insulin." "So that is what the lab looks at...insulin resistance and cell signaling. There have been lots of possible changes to insulin signaling proposed as the key mechanisms responsible for insulin resistance, but the reality is that insulin resistance isn't understood. So here is a list of possible research topics to investigate an d determine their relative role in insulin resistance. Excerpt 4 Some of the documented changes in insulin signaling as a result of diabetes are (numbers refer to Figure 4 in Excerpt 3): Decreased insulin receptor kinase activity upon binding of insulin to the receptor (2). Decreased binding of signaling effectors to the insulin receptor due to e Less phosphorylation sites on the insulin receptor (3) o Feedback inhibition on the signaling molecule, preventing its binding to the insulin receptor. Decreased signaling effector binding leads to defective downstream activation of the kinase cascade and second messenger signaling pathways (7), (8). Decreased GLUT4 (glucose transporter) fusion to the cell membrane and less glucose transported into the cell (4), (5). ons What is the general purpose it isnt supposed to? How do the effects of insulin resistance compound to decrease cellular responses to insulin? Hypothesize a mechanism by which the GLUT4 transporters fusion to the cell membrane could be decreased. 1. of feedback inhibition? What is the problem if feedback inhibition happens when 2. 3. ider the possible projects that Mia could study. a. Which project would you pick b. Why do you think this project is important? c. What kind o f experiments would you do? Licensed image in title block is © Itsmcjust Dreamstime.com, ID#28762251 Case copyright held by the National Center for Case Study Teaching in Science, University at Buffalo, State University of New York. Originally published October 3o, 2013. Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work. 8:25 AM 10/26/2015

Explanation / Answer

a. I would pick the first project. - decreased insulin receptor kinase activity

b. This project is important as the receptor kinase is responsible for the signalling pathway.

c. The experiments to be done would be:

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