choose an enzyme involved in the metabolic pathways, and find an inhibitor to th

Question

choose an enzyme involved in the metabolic pathways, and find an inhibitor to that enzyme included (i) the name of the enzyme and chemical structure of both the natural substrate and the inhibitor, (ii) whether the inhibitor is competitive, uncompetitive, or acts via another mechanism of inhibition, (iii) the Ki of the inhibitor, and (iv) a one page description of the proposed mechanism of inhibition which will require library research and should include description of where the inhibitor binds to the enzyme, whether the inhibitor is converted to a ‘suicide’ substrate.

Explanation / Answer

1)proteases .and natural occuring ptotease inhibitor are usually protein or peptidr

2) inhibitor are mostly competitive

3) smaller Ki means greater is inhibitory

Suicide inhibitor typically analogues of substrate are a type of irreversible inhibitor that cavalently bind.e.g serpin family of protein

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