After maximum tissue concentration is achieved following an IV bolus dose of dru

Question

After maximum tissue concentration is achieved following an IV bolus dose of drug, what can be said about the concentrations of drug in the central and tissue compartments? Select one: a. The decline in concentrations in both compartments are independent of each other. b. The decline in concentrations in both compartments follows zero-order kinetics. c. The concentrations in both compartments decline in parallel. d. The concentration in the central compartment continues to increase, and the tissue compartment concentration declines.

Explanation / Answer

a. The decline in concentrations in both compartments are independent of each other.

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