You are interested n the function of a protein. Mtm1, that has a PH domain, an S

Question

You are interested n the function of a protein. Mtm1, that has a PH domain, an SH3 domain, and a PTB domain. Mtm1 functions downstream of the insulin receptor and binds to this receptor in an insulin - dependent fashion via its PTB domain. You create mutant forms of Mimi that delete the various protein domains. You find that these mutations do not seem to affect the protein level or folding of Mim1. You examine the localization of Mtm1 and your results are summarized in Table 2. In Table 2, the D symbol indicates that the following protein domain is deleted. For example, mtm1 DPH indicates an Mtm1 protein that lacks the PH domain: mtm1DPHDSH3 indicates an mtm1 protein that lacks both the PH domain and the SH3 domain. Given what you know about these three protein domains and the data above, explain the role of the PH, PTB, and SH3 domains in localizing the Mtm1 protein.

Explanation / Answer

according to data

SH3 domain has no role in translocation because process to translocation is not affecting even in presence and abscence of it.so possibly its role in insulin receptor binding.

PTB domain mainly participate in process of translocation.

PH domain mainly assist the process of translocation.

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