Assume that the binding of one molecule of epinephrine to a seven-transmembrane

Question

Assume that the binding of one molecule of epinephrine to a seven-transmembrane helix (7TM) receptor (also called the G protein-coupled receptor, or GPCR) results in the activation of 130 Ga subunits. In addition, suppose that each activated adenylyl cyclase catalyzes the conversion of 30 ATP molecules to CAMP per second. (Assume that each G protein activates a single unique adenylyl cyclase.) Calculate the number of moles of cAMP that are produced per second. Enter your answer to at least two significant figures. Number mol cAMPs Note that these numbers are used for illustrative purposes only. The actual rates are different (and larger), and vary dependina on tvpe of receptor and requlatory oroteins that increase or decrease the rate of the

Explanation / Answer

Sol . As 130 Galpha subunits activating 130 cAMPase . Also, each cAMPase converting the 30 ATP molecules into cAMP/s .

So , total no. of molecules of cAMP produced by 130 cAMPases per second = 130 ×30 = 3900 molecules cAMP / s

As , 1 mole is equal to 6.022 × 1023  molecules .

So , to convert from molecules to moles , dividing no. of molecules by 6.022 × 1023   .

So , Total no. of moles of cAMP produced per second = 3900/6.022 × 1023   = 6.476 × 10-21 mol cAMP / s .

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