Assume that the binding of one molecule of epinephrine to a seven-transmembrane

Question

Assume that the binding of one molecule of epinephrine to a seven-transmembrane helix (7TM) receptor (also called the G protein-coupled receptor, or GPCR) results in the activation of 1.0 × 102 G subunits. In addition, suppose that each activated adenylyl cyclase catalyzes the conversion of 30 ATP molecules to cAMP per second. (Assume that each G protein activates a single unique adenylyl cyclase.) Calculate the number of moles of cAMP that are produced per second. Enter your answer to at least two significant figures.

Explanation / Answer

One molecule of epinephrine to 7TM receptor activates 1.0 x 102 = (100) G subunits.

Each adenyl cyclase converts 30 ATP molecules to cAMP per second.

Number of cAMP molecules produced per second = 100 x 30 = 3000

Each G subunit activates adenyl cyclase that converts ATP to cAMP. Hence, 3000 cAMP molecules are produced by Adenyl cyclase per second.

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