Assume that the binding of one molecule of epinephrine to a seven-transmembrane

Question

Assume that the binding of one molecule of epinephrine to a seven-transmembrane helix (7TM) receptor (also called the G protein-coupled receptor, or GPCR) results in the activation of 230 G? subunits. In addition, suppose that each activated adenylyl cyclase catalyzes the conversion of 40 ATP molecules to cAMP per second. (Assume that each G protein activates a single unique adenylyl cyclase.) Calculate the number of moles of cAMP that are produced per second. Enter your answer to at least two significant figures.

Explanation / Answer

One adenylyl cyclase catalyzes the conversion of 40 ATP molecules to cAMP per second.

Each G protein activates a single unique adenylyl cyclase. therefore 230 G alpha will activate=230 adenylyl cyclase

Each activated adenylyl cyclase catalyzes the conversion of 40 ATP molecules to cAMP per second.

therefore, 230 molecules of adenylyl cyclase will catalyse 230*40ATP mol;ecules per second= 9200 cAMP molecules.

from avogadro rule: one mole = 6.022×1023 molecules.

Or, 6.022×1023 molecules = 1 mole

therefore, 9200molecules of cAMP = (1/6.022)×1023 molecules*9200

=1527.4780/1023 molecules

=1.5274X10-20 moles per second.

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