3. You are interested in examining the regulation of the gene that encodes an en

Question

3. You are interested in examining the regulation of the gene that encodes an enzyme, Phosphoserine flippase (PSF), important in establishing the correct orientation of phospholipids. It is known that PSF is normally produced when cells are exposed to high levels of both calcium (Ca2+) and magnesium (Mg2+). MetA, MetB, and MetC, are important for binding to the promoter of the PSF gene and are involved in regulating its transcription. MetA binds to the ''A'' site, MetB binds to the ''B'' site, and MetC binds to the''C'' site in the promoter region. You create binding site mutations in the A, B, and C sites and observe what happens to transcription of the PSF gene. Your results are summarized in the Table below. For this table: ? = no transcription of PSF, + = low level of transcription of PSF, and ++ = high levels of transcription of PSF.

Explanation / Answer

a. is MetA is likely to be a gene activator or gene suppressor....................MetA is a PSF gene activator

b. is MetB is likely to be a gene activator or gene suppressor....................MetB is a PSF gene suppressor

c. is MetCis likely to be a gene activator or gene suppressor...................MetC showslow levels of transcription

d. Which transcription factors are normally bound to the PSF promoter in the presence of Ca2+ only..............MetC

e. Which transcription factors are normally bound to the PSF promoter in the presence of Mg2+ only..............MetA

f. Which transcription factors are normally bound to the PSF promoter in the presence of Mg2+ and Ca2+ only................MetA and C

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