Please help me answer this biochemistry question. I can\'t figure out which answ

Question

Please help me answer this biochemistry question. I can't figure out which answers are misplaced. Thank you in advance!!

The presence of multiple hexokinase isozymes (1-IV) for the phosphorylation of glucose enables specific organs to regulate carbohydrate metabolism in a uníque way. Hexokinase IV (blue curve in the plot below), also called glucokinase, is the predominant isozyme in liver and has distinct kinetic properties from the other hexokinase isozymes (representative curve in red). Note the difference in the shapes of the curves within the physiological r range of glucose concentration (4 to 6 mM). 0.8 0.6 glucokinase (hexokinase IV) 0.4 0.2 Please scroll down to continue. 0 26 8 10 12 14 Glucose concentration (mM)

Explanation / Answer

The Km of glucokinase is high because the affinity for glucose is less for the enzyme. It is active at higher concentration of glucose. Hence the first option "Km is in the range of physiological blood glucose levels for all hexokinase isoenzyme" should come under Hexokinase 1,ii or iii.

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