2,4-dinitrophenol (DNP) was a popular ingredient in diet pills in the 1930s befo

Question

2,4-dinitrophenol (DNP) was a popular ingredient in diet pills in the 1930s before it was discovered that moderate doses of the compound cause exceptionally high body temperature and even death. Complete the following passages detailing how DNP's mechanism of action explains why it causes both high body temperature and weight loss.

Answer choices: protons, ATP, sugars, ATP synthase, electrons, heat, NADH, cytochrome

2,4-dinitrophenol (DNP) causes Select answer membrane instead of returning to the mitochondrial matrix through Select ansiwer to pass directly across the inner mitochondrial proteins Because of DNP's effect on the mitochondrion, less energy is captured in the form of Select answer and more energy is instead wasted as heat.

Explanation / Answer

2,4-dinitrophenol (DNP) causes protons to pass directly across the mitochondrial membrane instead of returning to the mitochondrial matrix through ATPsynthase proteins (mobile electron carriers). Because of DNP's effect on the mitochondrion, less energy is captured in the form of ATP and more energy is instead wasted as heat.

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