CONSTANTS Hemoglobin-O2 Combining Capacity: 1.39 ml Og Hb O2 Solubility Coeffici

Question

CONSTANTS Hemoglobin-O2 Combining Capacity: 1.39 ml Og Hb O2 Solubility Coefficient: 0.003 ml 02/100 ml blood/torr EQUATIONS 1. Arteriovenous O2 content difference=-consumption O consumption cardiac output 2. Total arterial Or content HbO2+ dissolved Or Hb0s: (Hb conc)(Hb0: combining capacity)(% saturation) Dissolved O2 = (POK, solubility coefficient) 3. O2 delivery rate = (Total arterial 02 content)(cardiac output) idal solume) Certerial PCo arterial PCO,-mixed expiratory PCO) (arterial PCOb) 4. Dead space volume-(tidal volume) (Note: this equation assumes equivalency of alveolar and arterial PCO2.) 5: Dead space ventilation = (dead space volume)(respiratory rate) VD: Volume of gas per unit time that does not reach respiratory portion of lung 6. Total minute ventilation = alveolar ventilation + dead space ventilation Vs: Total volume gas per unit time entering lungs = tidal volume x respiratory rate 7. Alveolar ventilation= total ventilation-dead space ventilation VA: volume of gas per unit time that reaches the alveoli Watch your units! 1L-10dl

Explanation / Answer

If PO2 in the lungs is 120 and PO2 in the tissues is 30

a) the % of the oxygen carried by the hemoglobin will be unloaded in the tissues based on the normal saturation curve is 60 %

PO2 in tissues is 30 ,the steep region of the curve represents the unloading phase which allows large quantities of O2 to be released into the tissues.Considering PO2 to be 30 the corresponding % HbO2 is 60.that means 60 % of Hb is unloaded into tissues.

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