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1) How do comparisons between genomes of related species help refine gene annota

ID: 66206 • Letter: 1

Question

1) How do comparisons between genomes of related species help refine gene annotation?

Comparisons can help identify errors in gene annotation if the annotation of two genes with identical sequences and locations is different.

2)

Which of the following features are more like to be found in a non-functional pseudogene than in a functionally active gene?

Which of the following features are more like to be found in a non-functional pseudogene than in a functionally active gene?

Variations in the structure of similar genes can indicate the pathway of the species' evolution. Clones from one species can be used to fill the gaps in the genome sequence of the other one if they have identical sequences. Comparisons provide information on the identities and locations of all genes and regulatory sequences conserved between the two species.

Comparisons can help identify errors in gene annotation if the annotation of two genes with identical sequences and locations is different.

2)

Which of the following features are more like to be found in a non-functional pseudogene than in a functionally active gene?

Which of the following features are more like to be found in a non-functional pseudogene than in a functionally active gene?

introns missing the GT-AG splice junctions appropriate for this gene a promoter with signals identical to the promoter of another gene only one exon with a stop codon exons that produce a complete open reading frame when spliced together a terminal exon followed by signals for post-transcriptional processing

Explanation / Answer

1. Comparisons provide information on the identities and locations of all genes and regulatory sequences conserved between the two species.

Comparisons between genomes of related species help refine gene annotation by providing information on the identities and locations of all genes and regulatory sequences conserved between the two species.