Cells are treated with a small molecule called pifithrin-, which was originally

Question

Cells are treated with a small molecule called pifithrin-, which was originally isolated for its ability to reversibly block p53-dependent transcriptional activation.

Select three true statements:

p21 would be expressed, leading to cell cycle arrest. p21 would not be expressed, leading to loss of cell cycle arrest. In such cells, division would be less likely to occur, and they would be more likely to enter apoptosis. In such cells, apoptosis would be less likely to occur, and they would be more likely to divide. Puma would not be expressed, leading to more efficient inhibition of mitosis. Puma would be expressed, leading to more efficient inhibition of mitosis.

Explanation / Answer

* p21 would not be expressed, leading to loss of cell cycle arrest.

* Puma would not be expressed, leading to more efficient inhibition of mitosis.

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