1. Frederick Griffith accidentally discovered transformation when attempting to
ID: 6761 • Letter: 1
Question
1. Frederick Griffith accidentally discovered transformation when attempting to develop a vaccine for pneumonia. He injected mice with samples from S-strain (virulent) and/or R-strain (non-virulent) pneumococci bacteria (Streptococcus pneumonia). Which of the following results is not consistent with Griffith’s experiments?a. injected R-strain; mouse lives.
b. injected S-strain; mouse dies.
c. injected heat-killed S-strain; mouse lives.
d. injected mixture of heat-killed S-strain and live R-strain; mouse lives.
e. injected mixture of heat-killed R-strain and live S-strain; mouse dies.
Explanation / Answer
d. injected mixture of heat-killed S-strain and live R-strain; mouse lives In Griffith's experiment he specifically discovered transformation due to this very mixture. The heat-killed S-strain which is normally virulent was not able to kill the mouse when injected into the mouse alone as a control but when he mixed the heat-killed S-strain with the live R-strain, the R-strain transformed using DNA from the heat-killed S-strain and became virulent when it normally is non-virulent and the mouse died. So option d. saying that the mouse lived is the opposite of what occurred during his experiment.
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