Neutrophil infiltration at the site of injury characterizes the inflammatory res

Question

Neutrophil infiltration at the site of injury characterizes the inflammatory response. A person has a rare genetic disease which leads to lower expression (about 50 times lower than regular case) of selections and Ig-CAMs on the endothelial cell. What would be expected in this person in terms of neutrophil extravasations and why? What would be healing response if this person suffers from an injury? Expression of enzymes which degrades the extracellular matrix (ECM) characterizes wound environment. These enzymes are secreted by the inflammatory cells (i.e. neutrophils, macrophages) and wounded cells (i.e. endothelial cells). The level of these enzymes (with respect to time) was measured for two patients, A and B. What type of wound is present in patient 'A' and patient 'B'? In terms of tissue restoration, which patient will have earlier tissue restoration and why? Will there be any difference between patient 'A' and patient 'B' in terms of restoration process and in terms of final tissue restored after the healing process?

Explanation / Answer

3) a. Mutations that cause lower expression of selectins and Ig-CAMs ()on the endothelial cells cause decreased extravasation of neutrophils because of decreased immune response. Decreased expression of Ig-CAM (immunoglobulin-cell adhesion molecules) results in decreased recognition of antigens and thus, decreased immune response.

b). If this person is infected, it takes more time to heal because of decreased immune response.

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