Calculate the ATP yield for the complete oxidation of a 21-carbon saturated fatt

Question

Calculate the ATP yield for the complete oxidation of a 21-carbon saturated fatty acid (You should consider the B-oxidation steps, processing of acetyl-CoA through the citric acid cycle, and electron transport Production of one GTP should be considered the equivalent of production of one ATP. Enter your answer to three significant gt) 155 ATPs are gained for each 21-carbon fatty acid oxidized An error has been detected in your answer. Check for typos, miscalculations etc. before submitting your answer. Submit Answer Try Another Version 1 item attempt remaining

Explanation / Answer

Calculation of ATP yield for the oxidation of 21-carbon saturated fatty acid

activation of fatty acid = -2 ATP

number of beta-oxidation cycles = (21/2) - 1.5 = 9

ATP yield per cycle = 9 x 5ATP/round = 45 ATP

number of acetyl units = 9

9 acetyl CoA x 12 ATP/acetyl CoA = 108 ATP

propionyl CoA to succinyl CoA = -1 ATP

succinyl CoA to malate = 3 ATP

malate to pyruvate (NADPH) then to acetyl CoA = 3 ATP

acetyl CoA oxidation in Krebs cycle = 12 ATP

total ATP yield = -2 + 45 + 108 - 1 + 3 + 3 + 12 = 168 ATP

So 168 ATPs are gained for each 21-carbon fatty acid oxidized

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