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https://session.masteringbiology.com/myctitemView?assignmentProblemID-61802515&offset-next; Metro Cell Fall 15 Ch. 15/16 HomeworkMuscle Contraction (2 of 2): The Sarcomere and the Sliding-Filament Model (Bi... Help | Close « previous 18 of 24|next» Part B Contraction of the sarcomere: the sliding-filament model Contraction of a sarcomere, and thus contraction of the muscle as a whole, is accomplished by a cyclic sequence of interactions between actin (thin filaments) and myosin (thick filaments) in the sarcomere Understanding this sequence of events is essential to understanding the mechanism of muscle contraction at the cellular and molecular levels. Begin by considering a relaxed muscle. In this state, the myosin molecules of the thick filaments are not in contact with the actin of the thin filaments, and ADP and Pi are bound to the myosin heads. An action potential on the muscle cell plasma membrane initiates contraction of the sarcomeres from this relaxed state Drag the labels to their appropriate locations on the cycle diagram below BIND myosin head extends (pivots) relaxed muscle myosin releases P action potential and Ca2+ release POWER STROKE cross-bridge between myosin and actin is broken myosin head forms a cross-bridge with actin sliding-filament model 9 EXTEND myosin pulls actin toward center of sarcomere myosin binds ATP DETACH myosin hydrolyzes ATP to ADP and P reset ? help Submit Hints My Answers Give Up Review Part

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