Table 14.3 Potency factor volues for selected chemicals Sabstance Oral PF (mgkg-
ID: 702689 • Letter: T
Question
Table 14.3 Potency factor volues for selected chemicals Sabstance Oral PF (mgkg-dai Inhaled PF Ongkgda) Metals andl Inorgunic Arsenic Beryllium Cadmium Chromium VI Orgenic Componads Benzene Benzoltaipyrene (BaP) Chloroform 4 Diosane Fomaldehyde Meihylene chlorid Polychlorinated biphesyls (PCB) Tetrachlorvethylenc Trichlorcethylene (TCE 1.5 50.0 R.4 6.3 55 x 10-1 7.3 6.1 x 10- 1,1 x 10-3 29 x 10-? .10 81 X 10 7.5 X 10 0.4-2.0 5.2 x 10 LI x 102 A5 x 10- 1.65 x 10 04-20 2.0× 10-, 60 x 10-1 ource ORN, 2000, USEPA 1999Explanation / Answer
Arsenic and chloroform amount is same 0.1 mg/L
Weight of Adult = 70 Kg , Total consumption of contaminant = 2L/day* 5year*365 days/year = 3650 L
Amount consume by Adult = 0.1 mg/L * 3650 L = 365 mg
Life expectancy = 70 years = 70* 365 = 25550 days
daily dose by adult = 365 mg / 25550 days/70 Kg = 0.0002 mg /Kg/day
Refrence dose for Arsenic = 0.0003mg/Kg/day from litrature
quotient = daily dose/ reference dose = 0.0002/0.0003 = 0.6666
it is safe to use less than 1
Refrence dose for Chloroform = 0.01 mg/Kg/Day so quetient =daily dose/ reference dose= 0.0002/ 0.01 = 0.02
safe to use less than 1
Cancer risk for Arsenic = daily dose* Potency factor (slop) = 0.0002 mg/Kg/day * 50 Kg.day /mg = 0.01
Cancer risk for chloroform = daily dose* Potency factor (slop) = 0.0002 mg/Kg/day * 8.1 * 10-2Kg.day /mg
= 1.62 * 10-5
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