The more we learn about protein folding the more we understand that the process

Question

The more we learn about protein folding the more we understand that the process is the result of the minimization of free energy and the final structure will sit in a thermodynamic well as seen in protein folding funnels. Considering this process which of the following statements is true? O The depth of the well is determined solely by entropic contributions resulting from the formation of the hydrophobic core. O The final native structure represents the absolute lowest free energy value the peptide chain can achieve in all conditions. O Disulfide bonds are a stabilizing force in all protein structures. O The unfavorable entropic cost of forming the native conformation is offset by the favorable entropic increase of the solvent upon formation of the hydrophobic core. ONone of the above statements are true.

Explanation / Answer

Answer -

The unfavourable entropic cost of forming the native conformation is offset by the favourable entropic increase of the solvent upon formation of the hydrophobic core.

It is true because of the formation of the hydrophobic core, there is an entropic increase of solvent which eliminate the unfavourable entropic loss.

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