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Which of the following statements about oxidative phosphorylation by ATP synthas

ID: 70697 • Letter: W

Question

Which of the following statements about oxidative phosphorylation by ATP synthase is FALSE?

1. The electrochemical gradient across the inner mitochondrial membrane generated by electron flow is used to synthesize ATP.

2. Inhibitors disrupt electron flow as well as ATP synthesis.

3. Uncouplers dissipate the electrochemical gradient but electron transport continues without ATP production.

4. A proton gradient alone without a corresponding energy input is not sufficient to drive the synthesis of ATP.

5. ATP synthesis occurs via simultaneous conformational changes in protein subunits containing catalytic sites.

Explanation / Answer

The answer is

4. A proton gradient alone without a corresponding energy input is not sufficient to drive the synthesis of ATP.

During the ATP synthesis, the energy released from the electron transport chain is used to transport protons across the inner mitochondrial membrane. Then the ATP synthesis solely depends on the proton gradient only but not any other factor.

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