1=thalidomide 2=3 methylthalidomide 3=3 fluorothalidomide 14) How confident are

Question

1=thalidomide 2=3 methylthalidomide 3=3 fluorothalidomide 14) How confident are you with the following statement made by the authors, "(S)-3 appears to be more active than both (R)-3 and (0)-1 in lipopolysaccharide (LPS) induced TNF-R production enhancement produced from human peripheral blood lymphocytes cultivated in vitro roduced from human peripheral blood lymphocytes cultivated in vitro..?" (5 pts) 15) What seems to be wrong with this statement, "For example, while only (S)-2 inhibits tumor necrosis factor-R (TNF-a) production in the 12-0-tetradecanoylphorbol 13 acetate (TPA)/human leukemia HL-60 assay system, (R)-2 is more active than (S)-2 in the okadaic acid/HL-60 assay system." (based on ref 9a) (5 pts) 16) Why might a group be interestedi Hansen, T. P.,; Brown, M. L. Org. Lett. 2003, 5, 2865.) (5 pts)

Explanation / Answer

16). Azido analogue of thalidomide inhibit the proliferation of microvascular endothelial cells in humans (anti-angiogenic property). Its synthesis is simple and is a five step process that can be carried out using commonly available starting materials.

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