Biochemistry Informatics - Enzyme Cofactors and Kinetics Below are directions ht

Question

Biochemistry Informatics - Enzyme Cofactors and Kinetics

Below are directions

http://pdb.org

http://www.rcsb.org/pdb/staticHelp.do?p=help/viewers/ligandExplorer_viewer.html

http://www.rcsb.org/pdb/staticHelp.do?p=help/viewers/proteinWorkshop_viewer.html

1. The PDB page for 4DXH indicates that horse liver alcohol dehydrogenase is complexed to the cofactor and a/n form of the substrate. A. NAD; unreactive B. NAD; reactive C. NADH; unreactive D. NADH; reactive 2. 2. Overall, 4DXH has_ _subunit/s,_catalytic centers, and a Zn2 in each active site. Overall, 4DXH hassubunit/s,catalytic centers, and a Zn2* in each active site A. 2;2 B. 2;1 D. 1;2 3. The subunit-subunit interface is comprised of sandwich-like structure that is a/n with a A. parallel beta sheet; nonpolar interior B. parallel beta sheet; polar interior C. antiparallel beta sheet; nonpolar interior D. antiparallel beta sheet; polar interior

Explanation / Answer

The enzyme alcohol dehydrogenase belongs to the family dehydrogenase enzymes. It is mainly involved in the conversion of acetaldehyde to ethanol. This enzyme first isolated and studied form horse liver.

1)

The PDB page for 4DXH indicates that horse liver alcohol dehydrogenase is complexed to the cofactor NAD+ and a reactive form of the substrate. Thus, the correct option is (B).    

2)

Overall, 4DXH has 1 subunit and 2 catalytic centers, and a ZN2+ in each active site. Thus, the correct option is (D).

3)

The subunit-subunit interface is comprised of sandwich-like structure that is an antiparallel beta sheet with a polar interior. Thus, the correct option is (D).        

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