A pairing mechanism involving the R sequences (R = Recombination) brings V (V =

Question

A pairing mechanism involving the R sequences (R = Recombination) brings V (V = Variable) and J (J = Joining) elements together for linkage into a single [____] during antibody gene rearrangement. The R sequences occur in an inverted form on the 3 side of V elements and the 5 side of J elements. Pairing of the [____] leads to formation of a hairpin, a fold-back double helix between the [____]. The [____] contains any intervening, unused V and J elements, and removal of the hairpin loop joins the [____] V and J elements into a continuous exon.

(1) mRNA; V elements; J elements; intron; fused

(2) B cell; inverted R sequences; R sequences; intron; combined

(3) gene; splice site; DNA double helices; intron; unused

(4) exon; R sequences; inverted R sequences; hairpin loop; surviving

(5) hairpin loop; V and J elements; R sequences; hairpin loop; remaining

Explanation / Answer

(3) gene; splice site; DNA double helices; intron; unused

(2) B cell; inverted R sequences; R sequences; intron; combined

(5) hairpin loop; V and J elements; R sequences; hairpin loop; remaining

(4) exon; R sequences; inverted R sequences; hairpin loop; surviving

(1) mRNA; V elements; J elements; intron; fused

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