Hemagglutinin in the native state mediates binding of the [____] to sialic acid

Question

Hemagglutinin in the native state mediates binding of the [____] to sialic acid residues on host cell membrane. The virus is next internalized via [____] through a vesicle that becomes an endosome. In the [____] conditions of the mature endosome, the [____] molecule switches to a fusion-active state, with a loop domain forming a coiled-coil structure and an a-helix to insert into the [____] membrane and to bend, bringing the viral and cellular membranes into apposition and fusion.

Please pick one.

(1) HIV; Gp120; endocytosis; hydrophilic; plasma

(2) influenza virus; phagocytosis; hydrophobic; neuraminidase; lysosome

(3) influenza virus; exocytosis; acidic; neuraminidase; early endosome

(4) HIV; phagocytosis; neutral; hemagglutinin; late endosome

(5) influenza virus; endocytosis; acidic; hemagglutinin; endosome

Explanation / Answer

Answer. (5)

Hemagglutinin plays an important role in the entry of influenza virus in host cell. The internalization takes place via receptor-mediated endocytosis. In the presence of acidic conditions the hemagglutinin changes to a fusion active state resulting in coiled structure to be an insert in endosome membrane.

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